Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 22, Issue 1, Pages 85-100Publisher
BAILLIERE TINDALL
DOI: 10.1016/j.berh.2007.12.012
Keywords
osteoporosis; bisphosphonates; type I collagen; osteogenesis imperfecta
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Osteogenesis Imperfecta is a heritable disorder characterized by bone fragility and low bone mass, with a wide spectrum of clinical expression. This review gives an update on its classification, the recent developments in the understanding of its pathophysiological mechanisms, and the current status of bisphosphonate therapy. Other therapeutic approaches and future directions of research are briefly discussed.
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