Journal
CANCER GENETICS AND CYTOGENETICS
Volume 129, Issue 1, Pages 52-56Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0165-4608(01)00425-3
Keywords
-
Categories
Ask authors/readers for more resources
Biological characteristics of malignant tumors including head and neck squamous cell carcinoma (HNSCC) are greatly affected by genetic alterations. However, the relationship between chromosomal aberrations and pathologic tumor stage in HNSCC has not been elucidated. In 32 patients, DNA sequence copy number aberrations (DSCNA) were surveyed by comparative genomic hybridization (CGH) combined with a microdissection method. The average number of DSCNA was 15.3 per tumor and increased with tumor stage (P < .05). DNA copy number gain was detected at 3q26 similar to qter in 29 tumors (91%), and 13 of these tumors displayed marked DNA amplification. Tumor stage was linked with this amplification (P < .05). The increase in DSCNA and amplification of 3q26 similar to qter are likely to be useful markers for estimating tumor progression in HNSCC. (C) 2001 Elsevier Science Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available