Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 6, Issue -, Pages D1019-D1023Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/Horn
Keywords
SWI/SNF; chromatin remodeling; bromodomain; review
Categories
Funding
- NIGMS NIH HHS [5F32GM20229, GM49065] Funding Source: Medline
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In eukaryotes, processes requiring access to DNA are inhibited by the structural packaging of the genome. A number of specialized ATP-dependent chromatin remodeling enzymes have evolved to overcome this inhibition. One subset of these enzymes, SWI/SNF, plays a critical role in the regulation of transcription, often functioning in concert with nuclear histone acetyltransferases (HATs). It remains unknown how these activities are coordinated. However, recent results revealing that the bromodomain, a motif common in these remodeling factors, constitutes an acetyl-lysine binding domain might provide insight into this process. Bromodomains may serve a role analogous to the signal transduction SH2 domain, by providing a means to recruit remodeling complexes to acetylated chromatin regions or to allosterically modify their function post-recruitment.
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