Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 122, Issue 2, Pages 131-137Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0166-4328(00)00390-9
Keywords
cerebellum; deep cerebellar nuclei; motor performance; posture and equilibrium; spatial orientation
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The role of the dentate nucleus on spatial orientation, assessed by the Morris water maze test, and on postural sensorimotor performance, assessed by vertical grid, suspended wire, and rotorod tests? was investigated. Bilateral electrolytic lesions of the dentate nucleus slowed down the acquisition of the hidden platform task of the Morris water maze, without affecting long-term retention, the probe trial, and the visuomotor guidance necessary for swimming toward a visible goal. In addition, reversal learning was impaired in the submerged platform condition. The lesions did not affect any of the motor performance scores. The selective impairment seen during acquisition of the hidden platform task is similar to that previously reported in rats with combined lesions of the cerebellar hemispheres and dentate, indicating a specific role for this region in spatial orientation. (C) 2001 Elsevier Science B.V. All rights reserved.
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