Journal
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
Volume 28, Issue 2, Pages 269-279Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bpg.2014.02.004
Keywords
Medical ethics; Next generation sequencing; Whole genome sequencing
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While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results. (C) 2014 Elsevier Ltd. All rights reserved.
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