Journal
INFECTION AND IMMUNITY
Volume 69, Issue 8, Pages 5157-5161Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.8.5157-5161.2001
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Funding
- NIDDK NIH HHS [R37 DK027083, DK27083, R01 DK027083] Funding Source: Medline
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Wild-type Legionella pneumophila grows in human macrophages within a replicative phagosome, avoiding lysosomal fusion, while nonreplicative mutants are killed in lysosomes. Wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocks phagocytosis of an avirulent mutant, but not of wild-type L. pneumophila, without affecting membrane ruffling and actin polymerization. These results show that wild-type and mutant Legionella strains use different entry pathways. They suggest that PI3Ks are involved in phagocytosis of an avirulent L. pneumophila mutant and regulate the ability of microorganisms to generate a replicative phagosome.
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