Journal
COGNITIVE BRAIN RESEARCH
Volume 12, Issue 1, Pages 109-116Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0926-6410(01)00043-X
Keywords
schizophrenia; information processing; mismatch negativity; auditory evoked potential; ketamine; NMDA receptor
Ask authors/readers for more resources
Mismatch negativity (MMN) is a component of the auditory evoked event-related potentials (ER-P) that assesses automatic sound change detection and is disturbed in schizophrenic patients. Animal experimental evidence has linked the generation of MMN to the N-methyl-D-aspartate (NMDA) receptor. We investigated the neuromagnetic mismatch field (MMF) in healthy volunteers before and after intravenous application of a subanesthetic dose of the NMDA receptor antagonist ketamine (0.3 mg/kg). Ketamine had a significant influence on latency and dipole moment of the MMF, whereas the N100m latency of the standard tone was not prolonged and its dipole moment remained stable. Our results suggest that ketamine interferes with aspects of preattentive information processing and is in line with the view that disturbed NMDA receptor function may mediate the deficient auditory mismatch response in patients with schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available