Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 26, Issue 8, Pages 504-510Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(01)01908-9
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- NCI NIH HHS [CA27607] Funding Source: Medline
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A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation cf Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.
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