Report of three cases of circulating heparin-like anticoagulants

Clinically significant endogenous circulating heparin-like anticoagulant activity has been associated with hematological malignancies, liver damage, end other pathological conditions. The source of high plasma concentrations of endogenous heparin-like anticoagulants is poorly understood. We report three cases of circulating heparin-like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T-prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxls and deep-site hematoma to bleeding of biopsy site and occasional ecchymosis, (C) 2001 Wiley-Liss, Inc.