Journal
JOURNAL OF MASS SPECTROMETRY
Volume 36, Issue 8, Pages 889-901Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jms.190
Keywords
drug metabolism; immunosuppressive drugs; tacrolimus; SDZ-RAD; mass spectrometry
Funding
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1012622] Funding Source: National Science Foundation
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Different tacrolimus epoxides and dihydrodiol epoxides arising from the chemical oxidation of the parent drug are described. Open-chain tautomeric forms involving the lactone function were identified for the tacrolimus epoxides. Moreover, the identification by electrospray and electrospray linked scan mass spectrometry of an SDZ-RAD C-16-C-27 O-demethyl 17,18-19,20-21, 22 tris-epoxide new metabolite isolated from pig liver microsomes is reported. The in vitro immunosuppressive activity, using mixed lymphocyte reactions of the two macrolide reported oxidation compounds are discussed. Copyright (C) 2001 John Wiley & Sons, Ltd.
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