Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 8, Pages 589-598Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35085008
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A single family of proteases, the caspases, has long been considered the pivotal executioner of all programmed cell death. However, recent findings of evolutionarily conserved, caspase-independent controlled death mechanisms have opened new perspectives on the biology of cell demise, with particular implications for neurobiology, cancer research and immunological processes.
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