Journal
JOURNAL OF BACTERIOLOGY
Volume 183, Issue 16, Pages 4905-4909Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.16.4905-4909.2001
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Funding
- NIGMS NIH HHS [R01 GM050895, GM50895] Funding Source: Medline
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A family of 11 phosphatases can help to modulate the activity of response regulator proteins in Bacillus subtilis. Downstream of seven of the rap (phosphatase) genes are phr genes, encoding secreted peptides that function as phosphatase regulators. By using fusions to lacZ and primer extension analysis, we found that six of the seven phr genes are controlled by the alternate sigma factor sigma-H. These results expand the potential of sigma-H to contribute to the output of several response regulators by controlling expression of inhibitors of phosphatases.
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