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Transcriptional regulation by the phosphorylation-dependent factor CREB

Journal

NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 2, Issue 8, Pages 599-609

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/35085068

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The transcription factor CREB - for 'cyclic AMP response element-binding protein' functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

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