Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 11, Issue 4, Pages 488-497Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(00)00239-7
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Funding
- NEI NIH HHS [R01-EY11001] Funding Source: Medline
- NINDS NIH HHS [R01-NS19950] Funding Source: Medline
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Recent experimental and theoretical results in cat primary visual cortex and in the whisker-barrel fields of rodent primary somatosensory cortex suggest common organizing principles for layer 4, the primary recipient of sensory input from the thalamus. Response tuning of layer 4 cells is largely determined by a local interplay of feed-forward excitation (directly from the thalamus) and inhibition (from layer 4 inhibitory interneurons driven by the thalamus). Feed-forward inhibition dominates excitation, inherits its tuning from the thalamic input, and sharpens the tuning of excitatory cells. Recurrent excitation enhances responses to effective stimuli.
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