Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 291, Issue 3, Pages 197-207Publisher
URBAN & FISCHER VERLAG
DOI: 10.1078/1438-4221-00125
Keywords
death receptor; mitochondria; caspase; v-FLIP; v-IAP; Bcl-2
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Bacterial and viral pathogens have evolved sophisticated strategies to manipulate the host cell's life span to their own advantage. This is achieved by modifications of the intrinsic apoptosis program at several checkpoints: kinases, caspases and mitochondria. The goal of this review is to give an overview over the molecular mechanisms involved.
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