Journal
MOLECULAR CELL
Volume 8, Issue 2, Pages 281-289Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(01)00312-4
Keywords
-
Categories
Funding
- NCI NIH HHS [CA43703] Funding Source: Medline
Ask authors/readers for more resources
The arrest of secretion response (ASR) in sec mutants reversibly inhibits nuclear import and relocates nuclear proteins to the cytoplasm. sec mutants also relocate nucleoporins; however, endocytic and Golgi-to-vacuole transport mutants do not cause relocation. The ASR requires Wsc membrane proteins that are trapped along the secretory path, rather than those which are at the plasma membrane. The activity of the downstream kinase, Pkc1p, is also required; however, the Pkc1p MAP kinase cascade is not. sec mutants initiate compensatory transcriptional changes distinct from those of the unfolded protein response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available