Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 26, Issue 2, Pages 145-157Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2011.09.003
Keywords
insulin resistance; metabolic syndrome; fatty liver; adiponectin; mitochondria
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Funding
- Wellcome Trust
- U.K. NIHR Cambridge Biomedical Research Centre
- U.K. Medical Research Council Centre for Obesity and Related Metabolic Diseases
- Evelyn Trust
- Clinical Research Infrastructure Grant
- Medical Research Council [G0600717B] Funding Source: researchfish
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As well as improving diagnostic and clinical outcomes for affected patients, understanding the genetic basis of rare human metabolic disorders has resulted in several fundamental biological insights. In some cases understanding extreme phenotypes has also informed thinking about more prevalent metabolic diseases. Insulin resistance underpins the twin epidemics of obesity and type 2 diabetes as well as accounting for many of the metabolic problems encompassed by the term metabolic syndrome. This review provides a brief update on current understanding of human severe insulin resistance syndromes, before highlighting recent insights provided by studies in these rare syndromes into the molecular pathogenesis of elements of the metabolic syndrome. (C) 2011 Elsevier Ltd. All rights reserved.
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