Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 24, Issue 2, Pages 279-289Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2009.10.003
Keywords
cryptorchidism; hypospadias; testicular dysgenesis syndrome; endocrine disrupters
Categories
Funding
- European Commission
- Danish Medical Research Council
- Svend Andersen's Foundation
- Velux Foundation
- Danish Network on Endocrine Disrupters (DAN-ED)
- Novo Nordisk Foundation
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Paediatric Research Foundation
- Turku University Hospital
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The prevalence of male reproductive disorders, such as testicular cancer and impaired semen quality, is increasing in many, albeit not all, countries. These disorders are aetiologically linked with congenital cryptorchidism and hypospadias by common factors leading to perinatal disruption of normal testis differentation, the testicular dysgenesis syndrome (TDS). There is recent evidence that also the prevalence of genital malformations is increasing and the rapid pace of increase suggests that lifestyle factors and exposure to environmental chemicals with endocrine disrupting properties may play a role. Recent prospective studies have established links between perinatal exposure to persistent halogenated compounds and cryptorchidism, as well as between phthalates and anti-androgenic effects in newborns. Maternal alcohol consumption, mild gestational diabetes and nicotine substitutes were also identified as potential risk factors for cryptorchidism. It may be the cocktail effect of many simultaneous exposures that result in adverse effects, especially during foetal life and infancy. (C) 2009 Elsevier Ltd. All rights reserved.
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