Journal
LEUKEMIA RESEARCH
Volume 25, Issue 8, Pages 711-717Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0145-2126(01)00011-X
Keywords
insulin-like growth factor I receptor; chronic myelogenous leukemia; interferon-alpha; flow cytometry; RT-PCR
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Aiming to verify if insulin-like growth factor type I and its receptor (IGF-IR) are implicated on pathofisiology of chronic myelogenous leukemia (CML), we studied 35 patients with CML in chronic phase at diagnosis or during interferon-alpha (IFN-A) or hydroxyurea treatments. Cytometry flow analysis and reverse transcription PCR (RT-PCR) molecular assay for IGF-IR expression on peripheral blood cells from CML patients diagnosed didn't show statistical differences from the control group. Hydroxyurea treated patients had lower expression of IGF-IR in granulocytes, lymphocytes and monocytes (P < 0.01). We found statistical higher percentage of T and B lymphocytes positive for IGF-IR on IFN-A treated patients (P < 0.001). Also an increase of IGF-IR mRNA expression could be detected in this group when compared with patients in hydroxyurea therapy (P < 0.05). Our study suggest that IGF-IR is not directly implicated on CML installation and that the increased expression of IGF-IR on lymphoid cells of IFN-A treated patients could contribute to the immune recognition of malignant cell clone by enhancing immunecompetent cell proliferation and action. (C) 2001 Elsevier Science Ltd. All rights reserved.
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