Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 5, Issue 4, Pages 447-451Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1367-5931(00)00227-1
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Advances in polymer science have led to the development of several novel drug-delivery sytems. A proper consideration of surface and bulk properties can aid in the designing of polymers for various drug-delivery applications. Biodegradable polymers find widespread use in drug delivery as they can be degraded to non-toxic monomers inside the body. Novel supramolecular structures based on polyethylene oxide copolymers and dendrimers are being intensively researched for delivery of genes and macromolecules. Hydrogels that can respond to a variety of physical, chemical and biological stimuli hold enormous potential for design of closed-loop drug-delivery systems. Design and synthesis of novel combinations of polymers will expand the scope of new drug-delivery systems in the future.
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