Journal
JOURNAL OF MOLECULAR ENDOCRINOLOGY
Volume 27, Issue 1, Pages 11-29Publisher
SOC ENDOCRINOLOGY
DOI: 10.1677/jme.0.0270011
Keywords
-
Categories
Ask authors/readers for more resources
Mutations in the human genes encoding the tissue-specific transcription factors hepatocyte nuclear factor (HNF)1 alpha, HNF1 beta and HNF4 alpha, are responsible for maturity onset diabetes of the young (MODY), a monogenic dominant inherited form of diabetes mellitus characterized by defective insulin secretion of the pancreatic beta -cells. In addition, the mutated HNF1 beta gene causes defective development of the kidney and genital malformation. This review summarizes the main features of these transcription factors and discusses potential events leading to the specific disease phenotypes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available