Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 16, Issue 4, Pages 302-311Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/074873001129002024
Keywords
cfos; circadian; clock genes; pineal; vasopressin
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Funding
- NINDS NIH HHS [R01 NS24542] Funding Source: Medline
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Within the suprachiasmatic nucleus (SCN) is a pacemaker that not only drives circadian rhythmicity but also directs the circadian organization of photoperiodic (seasonal) timekeeping. Recent evidence using electrophysiological, molecular, and genetic tools now strongly supports this conclusion. Important questions remain regarding the SCN's precise role(s) in the brain's photoperiodic circuits, especially among different species, and the cellular and molecular mechanisms for its photoperiodic memory. New data suggesting that SCN clock genes may also function as calendar genes are a first step toward understanding how a photoperiodic clock is built from cycling molecules.
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