Journal
NETHERLANDS JOURNAL OF MEDICINE
Volume 59, Issue 2, Pages 66-75Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0300-2977(01)00131-0
Keywords
pathogenesis; systemic lupus erythematosus; apoptosis
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In recent years disturbances in the process of apoptosis and the clearance of apoptotic cells have been put forward as fundamental in the development of autoimmunity. In this review we will discuss the data which supply evidence for this theory. We will focus on SLE as the prototype of autoimmune disease and will review both animal studies and clinical studies in SLE patients. (C) 2001 Published by Elsevier Science B.V.
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