Journal
NATURE MEDICINE
Volume 7, Issue 8, Pages 947-953Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/90992
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Funding
- NIDDK NIH HHS [1R01-DK55758, T32-DK 07513-15] Funding Source: Medline
- NIGMS NIH HHS [T32-GM07491] Funding Source: Medline
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Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
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