Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 13, Issue 4, Pages 485-492Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(00)00240-4
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Funding
- NCI NIH HHS [CA58689] Funding Source: Medline
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Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking, Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effecters critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.
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