Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 45, Issue 8, Pages 2393-2396Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.8.2393-2396.2001
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We report that alteration in MurM, an enzyme involved in the biosynthesis of branched-stem cell wall muropeptides, is required for maximal expression of penicillin and cefotaxime resistance in the pneumococcus. Hungarian isolate 3191 (penicillin MIG, 16 mug/ml; cefotaxime MIG, 4 mug/ml) was a source of donor DNA in transformation experiments. Penicillin-binding protein DNA was insufficient to transform recipient strain R6 to full resistance. Further transformation with altered murM DNA was required for full expression of donor penicillin and cefotaxime resistance.
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