Journal
AMERICAN JOURNAL OF HEMATOLOGY
Volume 67, Issue 4, Pages 262-267Publisher
WILEY-LISS
DOI: 10.1002/ajh.1128
Keywords
platelet membrane GPVI; anti-GPVI antibody; collagen; platelet activation; SLE
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Platelet-collagen interaction is important in primary hemostasis and collagen receptors on the platelet surface include membrane glycoprotein (GP) Ia/IIa and VI, Platelets from a 47-year-old woman with systemic lupus erythematosus (SLE) and a mild bleeding symptom showed a defective collagen-induced aggregation and an impaired adhesion to collagen surface. The patient's platelets had a markedly decreased content of GPVI. The patient had an antibody against GPVI in serum and the patient's plasma induced aggregation and release reaction of normal platelets, These findings indicate that GPVI is an important receptor for collagen on the platelet surface, and that anti-GPVI antibody activates the platelets, resulting in aggregation, This is the first documented case of SLE who acquired a platelet-aggregating anti-GPVI antibody. (C) 2001 Wiley-Liss, Inc.
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