Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 65, Issue 8, Pages 1886-1888Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.65.1886
Keywords
hydroxy isothiocyanate; 2-(4-hydroxyphenyl)ethyl isothiocyanate; synergism; aminoglycoside; streptomycin
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Hydroxy isothiocyanates, especially 2-(4-hydroxyphenyl)ethyl isothiocyanate (hITC), were examined for antimicrobial synergism with several antibiotics against Escherichia coli and Staphylococcus aureus, using a multiwell plate system. hITC had antibacterial synergism, specifically with aminoglycoside antibiotics. The synergism was observed in synthetic medium (M9 minimal medium) or soybean casein digest broth,, but not in nutrient broth. Synergism was seen in the presence of certain sugars such as glucose, fructose, and maltose in the medium.
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