Journal
AMERICAN JOURNAL OF PSYCHIATRY
Volume 158, Issue 8, Pages 1326-1328Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.ajp.158.8.1326
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Objective: The authors investigated the relationship between anxiety-a facet of the Revised NEO Personality Inventory dimension of neuroticism-and serotonin 5-HT1A receptor binding potential. Method: Positron emission tomography with [C-11]WAY-100635 was used to estimate regional 5-HT1A binding potential in 19 healthy volunteers who completed the Revised NEO Personality Inventory. Correlation coefficients were calculated to determine the degree of association between 5-HT1A binding potential and personality inventory measures. Results: There was a significant negative correlation between 5-HT1A binding potential and anxiety in four regions: the dorsolateral prefrontal cortex. anterior cingulate cortex, parietal cortex, and occipital cortex. Conclusions: The inverse relationship between 5-HT1A receptor binding potential and anxiety is consistent with 1) animal models that have shown higher anxiety in mice lacking 5-HT1A receptors and 2) clinical trial data that have demonstrated antianxiety properties of partial 5-HT1A agonists.
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