Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 14, Issue -, Pages 2396-2403Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.14.216
Keywords
ball-mill; contact explosive; IBX; mechanochemical synthesis; quinazolin-4(3H)-one
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Funding
- DST (New Delhi, India)
- UGC (India)
- CSIR (India)
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Performing any synthesis using several arylamines and hypervalent iodine(V) reagents by direct mixing is unrealistic because of the high exothermic reaction or explosion. Herein we demonstrate, when anilines were substituted with an amide group at the orthoposition, successful chemical reactions could be performed due to intramolecular control. At maximum contact of the reacting substances, i.e., under solvent-free mechanochemical conditions, 2-aminobenzamides, aryl-, alkylaldehydes and the iodine(V) reagent o-iodoxybenzoic acid (IBX) led to substituted quinazolin-4(3H)-one derivatives in fair yields.
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