Hysteroscopic findings in 344 women with recurrent spontaneous abortion

Study Objective. To evaluate the prevalence of different anatomic factors in women with recurrent spontaneous abortion (RSA). Design. Retrospective analysis over 9 years (Canadian Task Force classification II-2). Setting. University hospital-affiliated endoscopic unit. Patients. Three hundred forty-four consecutive patients with RSA and 922 controls referred for abnormal uterine bleeding. Intervention. Diagnostic hysteroscopy. Measurements and Main Results. Major and minor uterine mullerian abnormalities (septate, unicornuate uteri) were found significantly more often in women with RSA than in controls (32% vs 6%, p < 0.001). The frequency of acquired uterine anomalies (submucous myomas, polyps) was significantly higher in controls (32% vs 9%, p < 0.001). No significant differences were observed between groups in frequency of adhesions (4% vs 2%). Conclusion. Major mullerian uterine abnormalities are associated with RSA, and minor uterine anomalies may be correlated with an increased risk of recurrent miscarriage.