Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue -, Pages 2139-2144Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.10.221
Keywords
bioinorganic chemistry; DNA; imidazole; metal-mediated base pairs; nucleic acids; nucleosides
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Funding
- Deutsche Forschungsgemeinschaft [SFB 858]
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The imidazole-Ag(I)-imidazole base pair is one of the best-investigated artificial metal-mediated base pairs. We show here that its stability can be further improved by formally replacing the imidazole moiety by a 2-methylimidazole or 4-methylimidazole moiety. A comparison of the thermal stability of several double helices shows that the addition of one equivalent of Ag(I) leads to a 50% larger increase in the melting temperature when a DNA duplex with methylated imidazole nucleosides is applied. This significant effect can likely be attributed to a better steric shielding of the metal ion within the metal-mediated base pair.
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