Journal
JOURNAL OF SURGICAL ONCOLOGY
Volume 77, Issue 4, Pages 237-242Publisher
WILEY-LISS
DOI: 10.1002/jso.1102
Keywords
fluorodeoxyglucose; PET; melanoma; lymph nodes; metastases
Funding
- NCI NIH HHS [CA74389] Funding Source: Medline
Ask authors/readers for more resources
Background and Objectives: The purpose of this study is to determine the tumor volume threshold for successful positron emission tomography (PET) imaging of melanoma nodal metastases. Methods: Review of a clinical series of patients who had FDG-PET imaging of regional lymph node basins followed by lymphadenectomy. Lymph node tumor volumes were calculated from direct measurements of metastatic nodule(s) in formalin fixed specimens. PET scan interpretations were correlated with histology to determine sensitivity. Sensitivity was correlated with the aggregate lymph node tumor volume in the nodal basin and with AJCC stage group. Results: Forty-five patients with 49 pathologically positive regional nodal basins comprised the study group. Median total basin tumor volume was 28.3 mm(3) (range 0.004-22,879 mm(3)). FDG-PET sensitivity for detection of all tumor volumes was 0.49. The observed 90% sensitivity threshold for detection of nodal metastases was greater than or equal to 78 mm(3). PET sensitivity Was 0.14 for detection of tumor volumes less than or equal to 78 mm(3). PET sensitivity differed by prescan AJCC stage: I-0.0; II-0.24; III-0.81; IV-1.0 (P<0.001). Conclusions: FDG-PET reliably detects lymph node tumor deposits greater than approximately 80 mm(3) volume, but sensitivity falls rapidly below th is. This amount of tumor is most likely to occur in patients with AJCC stage III or IV disease. J. Surg. Oncol. 2001;77.-237-242. (C) 2001 Wiley-Liss, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available