4.5 Article

One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

Journal

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue -, Pages 150-154

Publisher

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.10.12

Keywords

alkyl bromide; carbon monoxide; cyanohydrin; ethyl cyanoformate; multicomponent; radical reaction

Funding

  1. Ministry of Education, Culture, Sports, and Technology (MEXT), Japan [2105]
  2. Grants-in-Aid for Scientific Research [21106003, 23350045] Funding Source: KAKEN

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The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

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