Journal
CURRENT OPINION IN NEUROLOGY
Volume 14, Issue 4, Pages 483-489Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00019052-200108000-00009
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- NINDS NIH HHS [R29 NS37345, P50 NS38370, R01 NS38586] Funding Source: Medline
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Parkinson's disease is a common neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta. The loss of these neurons is associated with a glial response composed mainly of activated microglial cells and, to a lesser extent, of reactive astrocytes. This glial response may be the source of trophic factors and can protect against reactive oxygen species and glutamate. Aside from these beneficial effects, the glial response can mediate a variety of deleterious events related to the production of reactive species, and pro-inflammatory prostaglandin and cytokines. This article reviews the potential protective and deleterious effects of glial cells in the substantia nigra pars compacta of Parkinson's disease. Curr Opin Neurol 14:483-489. (C) 2001 Lippincott Williams & Wilkins.
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