Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue -, Pages 1406-1412Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.10.144
Keywords
cyclopeptoids; glycosidases; iminosugars; inhibitors; multivalency; mutivalent glycosystems
Categories
Funding
- Institut Universitaire de France (IUF)
- CNRS [UMR 7509]
- University of Strasbourg
- Agence Nationale de la Recherche (ANR) [11-BS07-003-02]
- French Department of Research
- Italian MIUR [PRIN 20109Z2XRJ_006]
Ask authors/readers for more resources
Cyclic N-propargyl alpha-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and alkyl spacer lengths by means of Cu(I)-catalysed azide-alkyne cycloadditions. Evaluation of these compounds as a-mannosidase inhibitors led to significant multivalent effects and further demonstrated the decisive influence of scaffold rigidity on binding affinity enhancements.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available