Journal
NATURE GENETICS
Volume 28, Issue 4, Pages 313-314Publisher
NATURE AMERICA INC
DOI: 10.1038/91070
Keywords
-
Categories
Ask authors/readers for more resources
Systemic lupus erythematosus (SLE) is a highly prevalent human autoimmune diseases that causes progressive glomerulonephritis, arthritis and an erythematoid rash(1,2). Mice deficient in deoxyribonuclease I (Dnase1) develop an SLE-like syndrome(3). Here we describe two patients with a heterozygous nonsense mutation in exon 2 of DNASE1, decreased DNASE1 activity and an extremely high immunoglobulin G titer against nucleosomal antigens. These data are consistent with the hypothesis that a direct connection exists between low activity of DNASE1 and progression of human SLE.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available