Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 46, Issue 2, Pages 132-136Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1111/j.8755-8920.2001.460203.x
Keywords
miscarriage; NK cell; pregnancy; recurrent spontaneous abortion
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PROBLEM: The aim of this study was to assess the role of natural killer (NK) cells in pregnant women with a history of recurrent spontaneous abortion (RSA). METHOD OF STUDY: Consecutive 66 pregnant women with a history of RSA were prospectively assessed for peripheral NK cell activity, percentage of the NK cell subsets, and subsequent pregnancy outcome. RESULTS: NK cell activity in women with subsequent live birth (group I) at 4-5 gestational weeks (GW) (mean +/- SD, 32.5 +/- 12.3%) significantly decreased at 6-7 GW (28.1 +/- 12.1%) and at 8-9 GW (28.0 +/- 11.8%). NK cell activity in women with subsequent abortion with normal chromosomes (group II) at 6-7 GW (41.2 +/- 19.0%) was significantly higher than that in group I women, while NK cell activity at 6-7 GW in women with subsequent abortion with abnormal chromosomes (group III) was the same as the level in group I women. CONCLUSIONS: High NK cell activity at 6-7 GW correlates with subsequent abortion with normal chromosomes.
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