Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue -, Pages 528-533Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.60
Keywords
cyclic depsipeptide; esterification; natural product; szentiamide; Xenorhabdus
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Funding
- European Community [223328]
- Deutsche Forschungsgemeinschaft (DFG)
- BMBF
- Hessen's Ministry of Higher Education, Research, and the Arts
- Frankfurt Initiative for Microbial Sciences (FIMS)
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The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.
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