Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue -, Pages 300-307Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.32
Keywords
asymmetric reduction; binolphosphoric acid; Bronsted acid; Hantzsch dihydropyridine; IR spectroscopy; real-time analysis
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Funding
- Excellence Initiative of the German federal government
- European Research Council
- Excellence Initiative of the German state government
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The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.
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