Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue -, Pages 1896-1899Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.219
Keywords
alkenes; epoxides; lithiation; synthetic methods; ylide
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Terminal epoxides undergo lithium 2,2,6,6-tetramethylpiperidide-induced alpha-lithiation and subsequent interception with Ph3P to provide a new and direct entry to beta-lithiooxyphosphonium ylides. The intermediacy of such an ylide is demonstrated by representative alkene-forming reactions with chloromethyl pivalate, benzaldehyde and CD3OD, giving a Z-allylic pivalate, a conjugated E-allylic alcohol and a partially deuterated terminal alkene, respectively, in modest yields.
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