Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 8, Issue -, Pages 1884-1889Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.217
Keywords
antioxidant; cytotoxicity; Selaginella tamariscina; selaginellin
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Funding
- China NSFC [21002018]
- Fundamental Research Funds for the Central Universities [HIT.BRET2.2010001]
- HIT.NSRIF [01107866, 01107986]
- program of excellent Team in HIT
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A new selaginellin named selaginellin O (1), along with three other known selaginellins (2-4) were isolated from Selaginella tamariscina (Beauv.) Spring. On the basis of spectroscopic analysis, the structure of selaginellin O was demonstrated to be 4-[(4'-hydroxy- 4-formyl-3-((4-hydroxyphenyl)ethynyl)biphenyl-2-yl)(4-hydroxyphenyl)methylene]cyclohexa-2,5-dien-1-one. Compound 1, 2 and 3 exhibited appreciable cytotoxic activity against cultured HeLa cells (human cervical carcinoma cells), as well as significant antioxidant activity.
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