Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 7, Issue -, Pages 1622-1635Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.191
Keywords
cyanobacteria; natural products; NRPS; PKS; ribosomal peptides
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Funding
- German Research Foundation (DFG) [Di 910/4-1]
- National Council for Scientific and Technological Development (CNPq)
- Brazilian Ministry of Science and Technology (MCT)
- German Academic Exchange Service (DAAD)
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Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.
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