Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 7, Issue -, Pages 937-943Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.104
Keywords
C-C fragmentation; endocyclic allene; natural product; total synthesis
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Funding
- NIH [GM-078145]
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The synthesis of a model endocyclic allene related to the vernonia allenes is described. Fragmentation of a suitable decalin derivative gave the simplified germacrane scaffold. Computational analysis of this and related substrates provides insight into the stereoelectronic requirements of C-C fragmentation. The overall strategy to access these and other sesquiterpenes and the key steps in the present sequence are also discussed.
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