Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 6, Issue -, Pages -Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.6.65
Keywords
asymmetric synthesis; electrophilic; fluorine; reagent; trifluoromethylation
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Funding
- JSPS in Japan
- CNRS in France
- JSPS [21390030]
- Grants-in-Aid for Scientific Research [21390030] Funding Source: KAKEN
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Since the discovery by Yagupolskii and co-workers that S-trifluoromethyl diarylsulfonium salts are effective for the trifluoromethylation of thiophenolates, the design and synthesis of electrophilic trifluoromethylating reagents have been extensively researched in both academia and industry, due to the significant unique features that trifluoromethylated compounds have in pharmaceuticals, agricultural chemicals, and functional materials. Several effective reagents have been developed by the groups of Yagupolskii, Umemoto, Shreeve, Adachi, Magnier, Togni and Shibata. Due to the high stability and reactivity of these reagents, a series of Umemoto reagents, Togni reagent and Shibata reagent are now commercially available. In this review, we wish to briefly provide a historical perspective of the development of so-called shelf-stable electrophilic trifluoromethylating reagents, although this field is in constant development.
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