Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 6, Issue -, Pages -Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.6.69
Keywords
alkylation; coumarin; fluorescent probe; glycine; protecting group
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Funding
- VW Foundation [I/82 605]
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The hydrochloride of the racemic amino acid (7-hydroxycoumarin-4-yl)ethylglycine, a versatile fluorescent probe in proteins, has been synthesized in five steps from commercially available (7-hydroxycoumarin-4-yl) acetic acid. The key step involves the alkylation of a glycine-enolate equivalent.
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