Journal
FEBS LETTERS
Volume 502, Issue 3, Pages 127-131Publisher
WILEY
DOI: 10.1016/S0014-5793(01)02680-1
Keywords
melatonin; reactive oxygen species; lymphocyte apoptosis; cellular redox regulation
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The antioxidant activity of melatonin (MEL) has been considered to constitute part of its physiological as well as pharmacological effects. However, as described herein we found a profound prooxidant activity of micro- to millimolar concentrations of MEL in the human leukemic Jurkat cell line. This prooxidant effect was increased in glutathione-depleted cells and counteracted by antioxidants. As a consequence MEL promoted fas-induced cell death. These data therefore indicate that MEL may be a modulator of the cellular redox status, but does not necessarily act as an intracellular antioxidant. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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