Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 5, Issue -, Pages -Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.5.4
Keywords
Biginelli reaction; DHPMs; neat; MCR; zeolite
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A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.
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