4.4 Article

Development of p-phenylbenzyl as a new protecting group:: protection and deprotection of alcohols

Journal

TETRAHEDRON LETTERS
Volume 42, Issue 32, Pages 5571-5573

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01058-9

Keywords

p-phenylbenzyl bromide; p-phenylbenzyl (PPB) ethers; p-phenylbenzyl trichloroacetimidate

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p-Phenylbenzyl is developed as a new 'PMB' like protecting group. p-Phenylbenzyl (PPB) ethers were prepared from alcohols with PPBBr-NaH or p-phenylbenzyl trichloroacetimidate-TfOH and subjected to oxidative deprotection using DDQ or DDQ (10 mol%)-3 equiv, Mn(OAC)(3). (C) 2001 Elsevier Science Ltd. All rights reserved.

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