New access to α-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under 'reduction-oxidative alkylation (R-OA)' conditions

(Z)-Fluoroalkene dipeptide isosteres serve as potential dipeptide mimetics. The present paper reports a new access to a-substituted (Z)-fluoroalkene isosteres utilizing an organocopper-mediated 'reduction-oxidative alkylation (R-OA)' reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.